Tracing of the region of the Sylvian fissure overlaid on three orthogonal projections of a normalized brain.

<p>R indicates right hemisphere.</p

CSF coordinates of between-group differences using the ‘New Segment’ approach.

*<p>x, y, z denote coordinates in DARTEL-template space.</p>**<p>FWE corrected for multiple comparisons.</p

Between-group comparison of mean signal intensity and total volume for left and right Sylvian fissure (ROI analysis).

<p>ml: Milliliters; SD: Standard Deviation.</p

CSF volume alterations in melancholic patients observed using the ‘New Segment’ algorithm.

<p><b>Upper row.</b> Left Sylvian fissure CSF increases in melancholic patients. <b>Lower row.</b> CSF volume decreases in spaces surrounding the medial and lateral parietal cortices. Voxels with p<0.001 (uncorrected) are overlaid on the study specific DARTEL template. <i>x</i> and <i>z</i> denote coordinates in DARTEL-template space. The color bar represents t value. R indicates right hemisphere.</p

Final Path Analysis Model.

<p>Model 3 was the best representation of the observed relationship between variables and examined the complex associations between Body Mass Index (BMI), neuroimaging results and behavioral data. BIS-11 = Barratt Impulsiveness Scale; Standardized regression weights for direct effects are shown *p<0.05 **p<0.001.</p

In-Scanner Negative Emotion Intensity Ratings.

<p>Mean (95% Confidence Interval) in-scanner negative emotion ratings elicited during each condition (Observe, Maintain and Regulate) (n = 28) *p<0.05.</p

fMRI task.

<p>Example images for Observe, Maintain and Regulate conditions.</p

Sample characteristics and behavioral measure results.

<p>Sample characteristics and behavioral measure results.</p

Global CSF and Total Intracranial volume in melancholic patients and healthy controls assessed with the different segmentation algorithms.

<p>ml: Milliliters; SD: Standard Deviation.</p

Clinical characteristics of melancholic patients.

<p>HAM-D, Hamilton Rating Scale for Depression (17 items); MDD, Major Depressive Disorder; MRI, Magnetic Resonance Imaging; SSRI, Serotonin Selective Reuptake Inhibitors.</p